Rampage 2 would likely be a sequel to the 2018 action-adventure film Rampage, starring Dwayne "The Rock" Johnson. The original movie, based on the classic arcade game, followed a primatologist (Johnson) as he tried to save his friend, a giant albino gorilla named George, from a destructive mutation that turned him into a massive, rampaging creature. Along with two other mutated monsters—a wolf and a crocodile—the trio wreaked havoc on cities, leading to a massive showdown in Chicago.

In Rampage 2, the storyline could potentially continue exploring the aftermath of the first film. George, now cured but still a giant, might face new threats, possibly from other mutated creatures or new experiments gone wrong. The sequel could introduce additional mutated animals or even explore a global scale of the mutation phenomenon, with new locations and challenges.

Dwayne Johnson's character might once again team up with George to save the world, blending intense action sequences with a focus on their unique bond. The film would likely maintain the high-energy, CGI-heavy style of the first, with larger-than-life battles and a mix of humor and heart.

The movie could also explore deeper themes, such as the ethical implications of genetic experimentation or the relationship between humans and animals, all while delivering the blockbuster spectacle that fans expect.